CU Boulder Engineering Faculty: Anushree Chatterjee

CU Boulder Engineering Faculty: Anushree Chatterjee

Hi everyone I’m Anushree Chatterjee I am
an assistant professor at the department of chemical and biological engineering
at University of Colorado Boulder. I’m also the founder of antimicrobial
regeneration consortium, a consortium that brings in labs across the globe to
accelerate development of antibiotics and diagnostics to address the challenge
of antimicrobial resistance. So my lab is interested in building smart therapies
and we do this by two ways: first we use basic science to understand how
organisms evolve so we use synthetic biology and
systems biology to understand evolution and learn from organisms. The other
aspect of my lab is to combine basic science and engineering to build
therapeutic platforms that can counter such evolving systems. So fast stands for
facile accelerated specific therapeutic and as the name suggests the idea is to
create therapies very fast and we do this by having a strong computational
and bioinformatics toolbox that can predict therapies within a matter of minutes. We
do synthesis within a matter of days. And we test them within a day. And this
entire process allows us to create therapies within a week, which is orders
of magnitude better than you know a year or so. Our second platform is a quantum
dot based antibiotic because here we are actually taking a semiconductor material
engineering it in a way that it would respond or be excited by similar such as
light or near-infrared light and here we’re trying to produce a very specific
radical called superoxide – which is actually produce by our own bodies – but
here we are producing it using the stimulus and this is again very very
effective against most drug-resistant clinical isolates. Our third platform is
called CHAOS and it stands for controlled hindrance of adaptation
organisms and the idea is very simple we want to create chaos within bacteria and
in this particular approach we really went back to the basics to understand
how organisms evolved. We learned from that and then we created a synthetic
biology approach where we perturb genes within the back here essentially create
chaos. So what I always look for: students who are willing to think out of the box
are willing to challenge themselves work hard and create solutions because then
that has the potential to save a lot of lives in
the future. So I believe chemical engineering and biological engineering
will play a huge role in addressing global health challenges whether it is
to create therapies devices or just understanding how these organisms are
behaving and all of that is truly addressed in a chemical and biological
teaching program

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